What’s the story of your relationship with your donor? Have you written this down so you can tell it to others? This is a gift to your organization.
Many major donors aren’t aware of everything your non-profit does in fulfillment of its mission. Make sure they (and you!) know.
If you are finding it difficult to connect your organization’s work to the passions and interests of the donor, it is because you have not adequately taken that donor into the problem or need.